Action required: Please refresh your browser
We have recently implemented some changes that require a hard refresh of your browser: Please hold down the CTRL-key and press the F5 key.
After a successful hard refresh, this message should not appear anymore.
More details about this topic are available here »
Poseida Therapeutics Presents Stem Cell Memory CAR-T Therapy for Prostate Cancer at 2018 Keystone Symposia on Emerging Cellular Therapies | ||
By: Nasdaq / GlobeNewswire - 14 Feb 2018 | Back to overview list |
|
SAN DIEGO, Feb. 14, 2018 (GLOBE NEWSWIRE) -- Poseida Therapeutics Inc. (“Poseida”), a San Diego-based company translating best-in-class gene engineering technologies into lifesaving cell therapies, presented preclinical data on P-PSMA-101 at the 2018 Keystone Symposia on Emerging Cellular Therapies: T Cells and Beyond. P-PSMA-101 is the company’s PSMA-specific stem cell memory CAR-T drug candidate for the treatment of prostate cancer, which is the most common cancer among men in the United States. “P-PSMA-101 is a first-in-class stem cell memory CAR-T therapy that exhibits a persistently high frequency of stem cell memory T-cells and mediates durable anti-solid tumor efficacy that surpasses previously established anti-PSMA CAR T-cell therapy in several in vivo models,” said Eric Ostertag, M.D., Ph.D., chief executive officer at Poseida. “Future development efforts are aimed at completing preclinical studies and preparing for filing of an investigational new drug application with the US FDA.” Jenessa Smith, Ph.D., of Poseida, led an oral presentation at the 2018 Keystone Symposia titled: “PSMA-Specific CAR T-Stem Cell Memory Therapy Eliminates Solid Tumor in Prostate Cancer Model.” The presentation covered the development of P-PSMA-101 via Poseida’s non-viral piggyBac™ DNA modification system and included a safety switch, a PSMA-specific CAR molecule and a selection gene – a combination of desirable features that may improve safety and therapeutic efficacy. Using piggyBac, researchers obtained >95% CAR+ T-cells after selection and expansion. Importantly, Poseida’s unique production methodology resulted in >60% T-stem cell memory (Tscm) cells, an early memory T-cell population that correlates with complete responses in CD19 CAR T-cell clinical trials. No evidence of tonic signaling or exhaustion was detected. Key findings include:
About P-PSMA-101 About Poseida Therapeutics, Inc. CONTACT: Corporate Communications Contact: Jason Spark Canale Communications 619-849-6005 Jason@canalecomm.com |
||
|
||
Copyright 2018 Nasdaq / GlobeNewswire | Back to overview list |